However, some studies on pediatric patients’ plasma and cell samples state that FLT3-ITD does not define the global leukemia metabolome but points to multiple metabolic feature disturbances, such as nucleosides, such as an increased abundance of guanine, hypoxanthine, inosine, adenosine, guanosine, and adenosine 5′-monophosphate and a decrease in tryptophan and 5-formyl-hydroxykynurenine30. This evidence concerns the gene FLT3 and leukemia.