S100A4 and cancer: Program cluster 2 (EMT II) includes SPARC, CTGF, FN1, VIM and other genes, which resemble the partial EMT and are related to cancer metastasis6, while Program cluster 5 (EMT I) includes VIM, S100A4, TIMP1, KRT19, etc., which prompt the progression of different cancer via EMT23–25.