PARP1 and infection: Our study has several limitations, including our inability to detect PARP activity in M.tb-infected cells (Supplementary Fig. 2d) which hindered the study of PZA in vitro (despite numerous attempts using virulent or attenuated strains, including M.bovis BCG, H37Ra and M. smegmatis; various MOIs; with or without IFNy priming; and timepoints ranging from 30 min to 48 h post-infection).