SOCS2 and neoplasm: Then we performed immunohistochemistry (IHC), among 72 hepatoblastoma samples collected in our hospital, we found that SOCS2 showed low expression in 43 (59.72%) hepatoblastoma tissues and only 16 (22.22%) in paired paraneoplastic liver tissues, and comparing the IHC scores, we found that the IHC scores of SOCS2 in paraneoplastic liver tissues were significantly higher than those of tumor tissues (Fig. 2C).