Consistently, in the early RA cohort (PEAC)46, low synovial HOTAIR expression in synovium was associated with a trend towards a lymphoid histological pattern (Fig. 9h) and HOTAIR expression was negatively correlated with CD138+ plasma cell infiltrates (r: 0.27, padj: 0.023) (Fig. 9i). The gene discussed is SDC1; the disease is rheumatoid arthritis.