Recently, Yang et al. (2022) identified five orphan TCRs that are associated with ankylosing spondylitis (AS) as well as acute anterior uveitis (AAU) and used yeast display library screening followed by subsequent validation to identify 26 HLA-B*27:05 restricted shared self-peptides and microbial peptides that activated the five AS- and AAU-derived TCRs. Here, HLA-B is linked to ankylosing spondylitis.