By usage of TCGA cancer and normal data, we found that SEMA3G was significantly downregulated in most of cancer types, including BLCA, BRCA, COAD, ESCA, GBM, HNSC, KICH, KIRC, KIRP, LUAD, LUSC, READ, STAD and UCEC (Figure 1A). This evidence concerns the gene SEMA3G and cancer.