To fully understand the role of CDKN1A, CDKN2A, CXCR4 and RAD51 in clinical melanoma patients, a genetic panorama with relevant clinical information (mutation spectrum, sex, diagnosis age, American Joint Committee on Cancer Metastasis Stage Code, overall survival, disease free, American Joint Committee on Cancer Tumor Stage Code) was drawn. The gene discussed is CXCR4; the disease is neoplasm.