CRTC1 and epilepsy: Neuronal excitability requires protein synthesis in response to altered neuronal stimulation, and risk factors for various epilepsies include dysregulation of RNA processing, RNA stability, transcription, and translation.76 TORC1 is a major nutrient- and energy-sensing serine/threonine kinase complex that controls cell growth and differentiation by coordinating core processes of transcription, translation, and autophagy.