POMC and epilepsy: Previous studies have shown that the irritable neurohormone corticotropin releasing hormone (CRH) can cause serious seizures and death of neurons in learning- and memory-related areas of the brain, while ACTH may act on CRH neurons located in the hypothalamus through the negative feedback regulation pathway to inhibit the overexcitation of marginal neurons caused by the excessive production and secretion of CRH to achieve anti-epilepsy effects [29, 30].