LL and diarrhea were more likely to be associated with larger tumor size, Shimada classification as NB, presence of IDRFs, high stage of INRGSS, high-risk group of INRG, MYCN amplification, retroperitoneal lymph node metastasis, laparotomy surgery, long period of operations, and vascular encasement (Table 3). The gene discussed is MYCN; the disease is neoplasm.