SENP3 and obesity due to melanocortin 4 receptor deficiency: To further define the in vivo role of SENP3 in YAP1 signaling and obesity, we investigated the in vivo expression of SENP3 and YAP1 in adipose tissue of Senp3flox/flox; Lyz2-Cre mice and Senp3flox/flox littermates.