The effect of TGFβ on endometabolomic profiles was also greater in SCD than NSCD cell cultures, with nine metabolites different at p < 0.001 in the SCD background, compared to only six different at p < 0.001 in the NSCD background [four in common], and more significant p values overall for the SCD cells [Figure 2G; Supplementary Table S6]. The gene discussed is TGFB1; the disease is Schnyder corneal dystrophy.