Herpes simplex virus 1 (HSV1), a double‐stranded DNA virus that causes recurrent lifelong incurable lesions, and Francisella, a Gram‐negative bacterium that is rapidly lethal after infection, are two different pathogens that activate AIM2, triggering the assembly of AIM2 PANoptosomes and the onset of PANoptosis.91, 92. This evidence concerns the gene AIM2 and infection.