Collectively, in the circulation and especially in the regional lymph nodes of breast cancer patients, a subpopulation of CXCR5+PD‐1+ cytotoxic T cells was frequently identified with TCM phenotype, expression of TIM‐3 and ICOS receptors, and had reduced capacity to secrete IFN‐γ. The gene discussed is CXCR5; the disease is breast carcinoma.