It functions critically in the DNA damage response, cell apoptosis, proliferation, and cancer development. It stimulates the activation of RAS in lung cancer,60 plays a role in deubiquitination and stabilization of FOXM1 in ovarian61 and breast cancer,62 promotes invasion in the colon63 and activates RhoA‐mediated invasion in prostate cancer.64 This evidence concerns the gene RHOA and prostate carcinoma.