It functions critically in the DNA damage response, cell apoptosis, proliferation, and cancer development. It stimulates the activation of RAS in lung cancer,60 plays a role in deubiquitination and stabilization of FOXM1 in ovarian61 and breast cancer,62 promotes invasion in the colon63 and activates RhoA‐mediated invasion in prostate cancer.64 The gene discussed is RHOA; the disease is cancer.