The relevance of the p62/Keap1/Nrf2 axis in cancer cells has been well described recently by Wei-Lun Hsu et al., who have reported that, in colon cancer cells exhibiting persistent Nrf2 activation, a natural compound interfered in the positive feedback loop p62-Keap1-Nrf2 axis of the noncanonical Keap1-Nrf2 pathway, concomitantly inhibiting autophagy activation and resulting in the death of cancer cells [47,48]. This evidence concerns the gene SQSTM1 and cancer.