Abnormalities in the expression of the GRIN2 gene in monogenic forms of epilepsy have been identified; however, NMDA receptors are widely expressed in the brain and play a critical role in excitatory neurotransmission, and epilepsy in such patients is only one of the symptoms along with movement pathologies, cognitive impairment, and severe forms of autism [63,64]. Here, GPRIN2 is linked to Cognitive impairment.