Insulin resistance reduces the bioavailability of nitric oxide, promotes low-grade inflammation in the blood vessels and the release of cytokines and chemokines, induces oxidative stress, and causes the overactivation of the renin–angiotensin–aldosterone system, all of which are interconnected and lead to the dysregulated function of vascular smooth muscle, impaired vasodilation, and fibrosis of the vessel wall [25,26]. The gene discussed is REN; the disease is Insulin resistance.