Suppression of KDM4B leads to downregulation of major tumor genes, including miR-17-92a-1 cluster host gene (MIR17HG), M-phase inducer phosphatase 1 (CDC25A), SRY-box 2 (SOX2), KIT ligand (KITLG), versican (VCAN), and syndecan 1 (SDC1), while suppressing MYCN function in both NB cells and xenograft models [77]. The gene discussed is SDC1; the disease is neuroblastoma.