SLC1A2 and opiate dependence: Chronic opioid intake led to (i) marked opioid dependence, as evidenced by the generation of strong withdrawal signs upon naloxone administration; (ii) prefrontal cortex alterations associated with the loss of control over drug intake, including significant demyelination, axonal degeneration, and reduction in levels of the glutamate transporter GLT-1; and (iii) striatal glial neuroinflammation and oxidative stress.