Similarly, we observed a marked upregulation of microglial activation, as evidenced by anti-CD11b labeling, in the 5xFAD group relative to the control group (AD, 51,210,100 μm3 [15,309,118–135,532,144]; control, 23,461,593 μm3 [14,499,170–27,924,110], p = 0.0162) (Table 1, Figure 4C). Here, ITGAM is linked to Alzheimer disease.