In the context of neuroinflammation, the 5xFAD group showed significantly higher average total surface volumes of anti-ACSA-2-labeled astrocytes (AD, 59,064,360 μm3 [27,815,500–222,619,280]; control, 20,272,722 μm3 [9,317,288–27,223,352], p = 0.0047) and anti-CD11b labeled microglia (AD, 51,210,100 μm3 [15,309,118–135,532,144]; control, 23,461,593 μm3 [14,499,170–27,924,110], p = 0.0162) than the control group. This evidence concerns the gene ITGAM and Alzheimer disease.