CD8A and hepatocellular carcinoma: A typical example showing the expression of ADAM17 and immune cell markers (CD3, CD4, CD8, CD56, CD68, CD163, and CD274) is presented in Figure 11A. Quantitative analysis showed that ADAM17 was positively correlated with the immune cell markers (Figure 11B,C; Supplementary Figure S1), which further verified the roles of ADAM17 in regulating the immune cell infiltration in HCC.