ADAM17 and cancer: As shown in Figure 1A,B, ADAM17 was overexpressed in most tumour tissues compared to normal tissues, including bladder (BLCA), cervical (CESC), bile duct (CHOL), colon (COAD), oesophageal (ESCA), head and neck (HNSC), liver (LIHC), rectal (READ), stomach (STAD), and endometrioid (UCEC) cancers; glioblastoma (GBM); and kidney clear cell (KIRC) and lung squamous cell (LUSC) carcinomas.