Concerning the heart and vasculature, apart from a single study demonstrating that low-dose losartan normalized PWV in iron-overloaded rats [57], as far as we are aware, these are the first data in T1DM regarding the cardioprotective effect of low-dose RAASis, especially of MR antagonists in monotherapy. The gene discussed is NR3C2; the disease is type 1 diabetes mellitus.