Moreover, recent findings indicate that tocotrienols exert an impact on numerous signaling pathways within cancer cells, including NF-κB-mediated pathways, phosphatidylinositol-3 kinase/phosphoinositide-dependent/Akt, Raf/Erk, and JNK-related pathways [207,208,209,210]. This evidence concerns the gene NFKB1 and cancer.