Vitamin Ks exhibit promising potential as anticancer agents and function as chemosensitizers when combined with other chemotherapy drugs targeting diverse cancers from various origins through multiple mechanisms, such as inhibition of cancer cell proliferation, survival, metastasis, and angiogenesis, and induction of intrinsic and extrinsic apoptosis, nonapoptotic cell death, autophagy, cell cycle arrest via inhibition of MAPK/ERK, NF-κB, wingless-related integration site (WNT), JNK, and phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathways [321]. This evidence concerns the gene AKT1 and cancer.