Initiation of the opioid receptor/PI3K/AKT/GSK3β signaling pathway under RIC can also lead to phosphorylation of Bcl-2 and breakdown of the Bcl-2/Beclin-1 complex, which plays an important role in stimulating autophagy and reducing mitochondrial damage in conditioned rats after cerebral ischemia [96]. The gene discussed is BCL2; the disease is brain ischemia.