According to the ACMG/AMP (American College of Medical Genetics and Genomics and the Association for Molecular Pathology) guidelines [23], we classified the variant, which was assessed as “deleterious” by the in silico prediction tools, and which was detected in SPTB, a gene known for its association to spherocytosis, as “pathogenic”. The gene discussed is SPTB; the disease is Spherocytosis.