IL5 and histiocytic sarcoma: Furthermore, we demonstrated that the macrophage signature and the IL-3/IL-5/GM-CSF pathway were significantly enriched in HS lesional skin compared with HS non-lesional and psoriatic skin, and the genes for the GM-CSF receptor (CSF2RA) and (CSFR2RB) were among the upregulated DEGs in HS lesional versus non-lesional skin (Table S1).