Furthermore, multiple immune pathways were significantly upregulated in HS lesional skin compared with non-lesional skin including IFNα/β (p < 0.0001), IFNγ (p = 0.0128), IL-1 (p = 0.0310), IL-3/IL-5/GM-CSF (p = 0.0010), IL-6 (p = 0.0038), IL-4/IL-13 (p < 0.0001), IL-12 (p = 0.0009), and IL-23 (p < 0.0001). This evidence concerns the gene IL5 and histiocytic sarcoma.