MTDH and lung cancer: FHIT also negatively regulates EMT through negatively regulating an EGFR/Src/ERK/Slug signaling axis in human bronchial cells [44] and by positively regulating miR-30c expression, which suppresses EMT and metastasis by directly targeting metastasis genes Metadherin (MTDH), High-mobility group AT-hook2 (HMGA2), and the mesenchymal markers Vimentin (VIM) and Fibronectin (FN1) in human lung cancer [45].