SNAI1 and lung adenocarcinoma: Indeed, we observed a significant positive correlation between higher SNAIL expression and worse prognosis in human lung adenocarcinoma (please note that in addition to suppressing FHIT expression, SNAIL has many other known functions that contribute to worsen cancer prognosis [13,14,48], and these mechanisms may also be involved in the worse lung adenocarcinoma prognosis).