MAPT and Alzheimer disease: The hippocampus is the brain region that displays the main neuropathological characteristics of AD, including extracellular oligomeric amyloid β (Aβ) peptide and parenchymal amyloid plaque deposition and the intracellular accumulation of hyperphosphorylated tau protein (p-Tau), which are associated with synaptic dysfunction, neuroinflammation, and progressive cognitive deterioration [5,6].