ADGRG2 and cancer: We examined the expression of ADGRG2 in 33 kinds of cancers using TCGA (tumor and normal data) cohorts (Figure 1A), resulting in most cancer patients’ ADGRG2 being down-regulated, while it was preeminently higher in four types of cancer, including cholangiocarcinoma (CHOL), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), and thyroid carcinoma (THCA).