Then, the up-regulated expression of ADGRG2 was verified in unpaired HCC samples (202 normal tissues vs. 243 tumor tissues) in ICGC_LIHC (Figure 1B), paired HCC tissues (50 pairs) in TCGA (Figure 1C), and the GEO database (Figure 1D,E). This evidence concerns the gene ADGRG2 and neoplasm.