CDKN1B and neoplasm: For example, miR-221 and miR-222 can behave as oncogenes by inhibiting the expression of p27 in various types of tumors (thyroid, glioblastoma, prostate, lung, etc.)[118,119,120] and also as tumor suppressors by inhibiting proto-oncogen KIT in erythroleukemia [121]; miR-20a is a tumor suppressor in hepatocellular carcinoma [122] oral squamous cell carcinoma [123] and suppressor cells of myeloid origin (MDSCs) [124], and a potential oncogene in gliomas [125], colon cancer [126] and gastric carcinoma [127].