PHLPP2 and neoplasm: In the study by Huang et al. [153], both in vitro and in vivo, the environmental compound B[a]P/B[a]PDE decreased the expression of the PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2) protein, an important tumor suppressor that regulates the Akt signaling pathway [154], which is related to the positive regulation of proinflammatory markers such as NFAT/NFκB, TNFα and COX-2.