OTX2 and retinal detachment: The analysis of the expression of a subset of genes in retinectomy samples from patients affected by proliferative vitreoretinopathy (PVR), an inflammatory complication of retinal detachment, showed an association between OTX genes expression and severity of the disease: those samples expressing OTX2, VEGFA, TP53, and TP63 are characterized by more severe PVR and patients require a greater number of surgical procedures, whereas samples with high OTX1 expression came from patients with a better prognosis [51].