OTX1 and malignant colon neoplasm: Similarly, OTX1 interacts with lncRNA HNF1A-AS1 and PBX3 in colon cancer to activate the extracellular-signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway and promote angiogenesis via the PBX-OTX1-VEGF axis [143].