OTX1, but not OTX2, is expressed in specific subsets of B-cell non-Hodgkin’s lymphomas (NHL): in particular, Omodei and colleagues detected OTX1 expression in nearly all diffuse large B-cell lymphomas, Burkitt lymphomas, and high-grade follicular lymphomas, but not in precursor-B lymphoblastic lymphoma, chronic lymphocytic leukemia, marginal zone, and mantle cell lymphomas, or multiple myeloma. Here, OTX1 is linked to B-cell chronic lymphocytic leukemia.