In fact, oncogenic properties exerted by OTX2 are associated with MYC, another typically amplified and/or overexpressed gene in medulloblastoma [104], which is directly induced by OTX2 [96] and frequently colocalizes with OTX2 [105] to promoters of MB [104] and embryonic/neural stem cell specific genes [106]. This evidence concerns the gene OTX2 and medulloblastoma.