In addition to the main pathway of CIN development due to the loss of p53 function, amplifications in such signaling pathways as RTK/RAS/MAPK, including HER2, epidermal growth factor (EGFR), MET and FGFR2, were detected in CIN tumors [100]. This evidence concerns the gene ERBB2 and cervical squamous intraepithelial neoplasia.