CD274 and neoplasm: The nanomaterial has the ability to modulate the immunosuppressive tumor microenvironment through a trinity of strategies, including degradation of the ECM to promote NPs accumulation and immune cell infiltration, triggering of the ICD through NIR-II PTT and GT to enhance tumor immunogenicity, and blocking of PD-L1 immunosuppression through a PD-L1 inhibitor.