Mutations in the gene encoding SLURP-1 were detected in patients with Mal de Meleda, a rare autosomal recessive skin disorder characterized by transgressive palmoplantar keratoderma [18,19,20]; some mutations located in loops I and II and the head of SLURP-1 may potentially drive the disease [21]. Here, SLURP1 is linked to Palmoplantar keratoderma.