CAV1 and melanoma: Indeed, when we evaluated the formation of the CAV1/E-cad complex in the presence of PGE2 in murine melanoma B16F10 cells that simultaneously overexpressed CAV1 and E-cad, the CAV1/E-cad ratio in CAV1 immunoprecipitates decreased at least 3-fold when compared to untreated cells, suggesting that CAV1 was released from the complex with E-cad (Figure 1D–G).