Indeed, our group has shown that in the absence of E-cad, CAV1 phosphorylation on tyrosine-14 (Y14) promotes signaling via a novel Rab5-Rac1 axis and, in doing so, enhances migration and invasion in vitro, as well as metastasis in a melanoma model in vivo [39,45,46,47,48]. Here, CDH1 is linked to melanoma.