The same behavior was observed for the abdominal tumor mass formed in the mice, where CAV1 promoted abdominal metastasis in A375 (CAV1) cells (0.475 ± 0.005 g), but E-cad partially decreased this behavior in A375 (E-cad) cells (0.286 ± 0.01 g). This evidence concerns the gene CAV1 and neoplasm.