CAV1 and neoplasm: To test the effect of PGE2 on the tumor suppressor properties of the CAV1/E-cad complex in vivo, C57BL/6 mice were injected subcutaneously with B16F10 (mock), B16F10 (CAV1), B16F10 (E-cad), or B16F10 (CAV1/E-cad) cells in the absence or presence of PGE2 (−/+ PGE2), and the volume of the tumors was measured at different time points (Figure 3A).