Consistently, single-cell RNA-seq analysis of nonmalignant tumor tissues and HGOSC tissues was utilized to investigate the distribution of SFRP2 in TME and a novel subset with the highest enrichment of SFRP2 and CAF markers (COL6A1, COL6A2, FAP) was identified (Figure 7C–F). Here, COL6A2 is linked to neoplasm.