Fu et al. [181] used the mass spectrometry protein profiles of exosomes extracted from the serum of GC patients and a cell culture supernatant and found a decreased level of tripartite motif-containing 3 (TRIM3), a member of the TRIM subfamily of the RING-type E3 ubiquitin ligases, in the serum of GC (n = 80) and healthy patients (n = 80). This evidence concerns the gene TRIM3 and gastric cancer.