Recently, very few targeted studies have focused on the characterization of only one blood protein as a putative diagnostic marker of GC (i.e., plasma sHLA-G [43,50], plasma DEK [48], and serum IGF-1), with most targeted works investigating more combined proteins (i.e., PD1 and PDL1 [45,61], PGI and PGII [53,55], cytokines, and, particularly, IL-6 [55,56,70] and TNF-α [51,55]. This evidence concerns the gene CD274 and gastric cancer.