TIMP4 and Fabry disease: After FD modeling, FD eyes of gene defect rats showed a significant reduction of bipolar axon length in the central and mid-peripheral retina compared to non-FD eyes, while similar differences were not observed in wild-type rats (Paired T-test, central: Timp4+/+ p = 0.1129, Timp4+/− p = 0.0398 < 0.05, Timp4−/− p = 0.392; mid-peripheral: Timp4+/+ p = 0.1674, Timp4+/− p = 0.0087 < 0.01, Timp4−/− p = 0.0071 < 0.01; peripheral: Timp4+/+ p = 0.1065, Timp4+/− p = 0.6741, Timp4−/− p = 0.1219) (Figure 3C,D).