TIMP4 and myopia: This study identified two TIMP4 LoF variants of the TIMP4 in seven of 928 probands with early-onset high myopia, and the defect of the TIMP4 was significantly enriched in eoHM compared to 5469 non-myopia controls (p = 3.7 × 10−5) and the general population (p = 2.78 × 10−9).