CREM and neoplasm: In the present study, in addition to the inflammatory mediators described above, eight genes were investigated for which there was evidence from previous studies that (1) their expression might be affected by extracellular acidosis [3], and that (2) they are important for tumor malignant behavior, such as migration (e.g., Txnip, Per3, Ypel3), proliferation (e.g., Crem, Gls2, Per3, Ypel3), adhesion (e.g., Pink1, Txnip), metastasis (e.g., Pink1, Txnip), apoptosis, and necrosis (e.g., Aox1, Acat2, Crem, Per3, Txnip).