Finally, because both the ovaries and the liver are innervated by sympathetic fibers [8,16], we aimed to determine if increases in leptin due to diet-induced obesity during infancy and development might simultaneously increase NE levels in the liver and ovaries, thereby providing a tenable connection between obesity and SNS hyperactivation with two interrelated pathologies in women, such as polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD) [18,19]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.