The genome instability associated with EEPD1 defects suggests that EEPD1 mutations might be found in cancers; however, these have not been detected [65], perhaps because the loss of EEPD1 is too destabilizing to sustain rapid cancer cell division in the face of oncogenic stress, nutrient deprivation, hypoxia, and ROS associated with immune inflammation. This evidence concerns the gene EEPD1 and cancer.