R-loops can be resolved by RNA unwinding by the helicases senataxin, aquarius (AQR), Werner syndrome protein (WRN), Bloom syndrome protein (BLM), regulator of telomere elongation helicase 1 (RTEL1), petite integration factor (PIF1), Fanconi anemia complementation group M (FANCM), alpha-thalassemia/mental retardation, X-linked (ATRX), and CRISPR-associated DinG protein (CasDinG) [247,248,249,250]. The gene discussed is RTEL1; the disease is thalassemia.