HIF1A and hepatocellular carcinoma: For example, treatment with the TX-402 inhibitor of HIF-1α expression downregulates the transcription of HIF-1α target genes GLUT-1 and erythropoietin but not MMP-7, MMP-14, or Ets-1 when hepatocellular carcinoma HepG2 and Hep3B were cultured in hypoxic conditions (1% oxygen) [117].