Considering that ORF15 is a mutation hotspot of RPGR (Figure S1), a great number of variants associated with this region are uploaded in the database of single nucleotide variants (dbSNP), commonly used worldwide to detect variants and diagnose hereditary genetic diseases and on which online databases and tools such as HGMD and Ensembl rely [11,12]. This evidence concerns the gene RPGR and hereditary disease.