Hyperchromatic cells with nuclear and cytoplasmic irregularities in case of severe bacterial vaginosis of a pre-menopausal woman raises the possibility that the interleukins modified the contribution between PI3K and p53 Rho-Rac [54,55,56,62,91], therefore elucidating the presence of binucleated superficial and intermediate cells by irregular nuclear division (Rho, cdc42) [92,93] and condensed chromatin (Rac) [87,94]. Here, TP53 is linked to bacterial vaginosis.