Aldosterone and mineralocorticoids activate the mineralocorticoid receptor (MR) causing inflammation and fibrosis in the heart, fibrosis, remodeling in the blood vessels, tubulointerstitial fibrosis and glomerular injury in the kidney, etc. However, all the studies have consistently demonstrated that concomitant high sodium intake and hypertension are obligatory components of this process [1,2,3,4,5,6]. The gene discussed is NR3C2; the disease is Hypertension.