Among them, bis(4-hydroxy)benzophenone oxime ether derivatives, including 229 (IC50 75 nM), 230 (IC50 46 nM), and 231 (IC50 77 nM), were shown to possess estrogen receptor (ER) agonist properties associated with noticeable antiproliferative activities arising through an ER-independent mechanism in cancer cells [216]. Here, ESR1 is linked to cancer.