TKT and cancer: While assessing their mechanistic effects on BRAFV600E, EGFR TK kinases, and tubulin polymerization, as well as for their potential to reverse efflux-mediated resistance developed by cancer cells in vitro, compound 198 strongly inhibited the activity of BRAFV600E, with an IC50 value of 0.9 μM, while the inhibitory activity of its analog 197 was more pronounced against EGFR TK, with an IC50 of 0.07 μM [199].