EGFR and cancer: The evaluation of these compounds for their effect on tubulin polymerization, EGFR TK kinases, KAF and BRAFV600E, as well as for their effect on reversing the efflux-based resistance developed by cancer cells, revealed that EGFR was strongly inhibited by 202 and 204, with analogs bearing 1-isopropyl-piperidin-4-one linker showing the best inhibition against KAF [200].