The key findings are: (1) PEMT mRNA expression exhibits tissue-specific variations in all three tissues, being lower in vis AT than in sc and liver; (2) the PEMT mRNA expression in vis AT correlates with diabetes and NASH; and (3) rs4646404 is associated with vis PEMT mRNA expression. The gene discussed is PEMT; the disease is metabolic dysfunction-associated steatohepatitis.