PEMT-mediated alterations in the PC/ phosphatidylethanolamine (PE) ratio are associated with the development and progression of non-alcoholic fatty liver disease (NAFLD) and its successor, non-alcoholic steatohepatitis (NASH), as well as liver failure and impaired liver regeneration in humans [9,10]. Here, PEMT is linked to metabolic dysfunction-associated steatohepatitis.