In early IUGR, there was a statistically significant increase in maternal blood plasma levels of Adiponectin (ADIPOQ), Alpha-2-macroglobulin (A2M), Gelsolin (GSN), Pregnancy zone protein (PZP), Protein S100-A9 (S100A9), Serum albumin (ALB). The gene discussed is A2M; the disease is fetal growth restriction.